12/3/2023 0 Comments Side effect of too much oxygen![]() Certainly oxygen exposure does correlate with BPD defined as the use of supplemental oxygen at 36 weeks of gestation. 3 The clinical contribution of oxygen to BPD has been less clear because sick infants generally require both ventilatory support and supplemental oxygen and the use of both therapies track in parallel during the weeks after birth. 2 These authors also reported that 100% oxygen caused inflammation, fibrosis, and ‘emphysema’ in the lungs of newborn mice in 1976. Our goal is to summarize clinical and animal model observations to build the concept that the effects of oxygen exposure of the newborn are likely to be modulated by multiple mechanisms such that the risk of oxygen toxicity may differ for each infant, depending on antenatal history, age after birth, and care strategies.īronchopulmonary dysplasia (BPD) has been the poster child for oxygen toxicity in the preterm since the original description of the disease by Northway et al. The focus of this review is on longer term effects of oxygen on the newborn rather than on the acute effects associated with oxygen use for resuscitation, which are reviewed in other papers in this monograph. ![]() Much of the data for oxidant injury and long term effects come from animal models, which inform us about what can happen, but do not establish what does happen to sick preterm infants. Therefore, a balanced perspective of the scientific and clinical aspects of oxygen use is needed, especially for the preterm. 1 The use of oxygen thus has a risk to benefit equation just as for any other drug. However, recent research reviewed in this monograph demonstrates that surprisingly short exposures to oxygen can alter long term biochemical indicators of oxidant stress and may adversely affect outcomes. Oxygen is the most frequently used effective and essential drug for the care of the newborn. ![]()
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